Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation
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چکیده
منابع مشابه
Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation
Persistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the quantitative requirements of in vivo immune control for epitope presentation and recognition rem...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2014
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1004220